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Literature summary for 3.4.21.22 extracted from
- Emicizumab, a humanized bispecific antibody to coagulation factors IXa and X with a factor VIIIa-cofactor activity (2018), Int. J. Hematol., 111, 20-30 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| emicizumab | factorIXa/factorX bispecific antibody. Emicizumab functions as a cofactor to promote the factor IXa-catalyzed factor X activation | Homo sapiens | |
| Factor VIIIa | factor VIIIa may directly modulate the active catalytic site of factor IXa to increase kcat of the factor IXa-catalyzed factor X activation | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Factor X + H2O | Homo sapiens | - |
Factor Xa + ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Factor X + H2O | - |
Homo sapiens | Factor Xa + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FIXa | - |
Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.048 | - |
Factor X | in the presence of emicizumab, pH and temperature not specified in the publication | Homo sapiens | |
| 2.1 | - |
Factor X | in the presence of factor VIIIa, pH and temperature not specified in the publication | Homo sapiens |
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