Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.22 extracted from

  • Sakurada, I.; Endo, T.; Hikita, K.; Hirabayashi, T.; Hosaka, Y.; Kato, Y.; Maeda, Y.; Matsumoto, S.; Mizuno, T.; Nagasue, H.; Nishimura, T.; Shimada, S.; Shinozaki, M.; Taguchi, K.; Takeuchi, K.; Yokoyama, T.; Hruza, A.; Reichert, P.; Zhang, T.; Wood, H.B.; Nakao, K.; Furusako, S.
    Discovery of novel aminobenzisoxazole derivatives as orally available factor IXa inhibitors (2017), Bioorg. Med. Chem. Lett., 27, 2622-2628 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-chloro-N-[3-methyl-1-(4-methyl-2-nitrophenyl)pyrrolidin-3-yl]-4-(4H-1,2,4-triazol-4-yl)benzamide
-
Homo sapiens
N-[(3R)-1-(3-amino-4,5-dichloro-1,2-benzoxazol-7-yl)pyrrolidin-3-yl]-2-chloro-4-(4H-1,2,4-triazol-4-yl)benzamide
-
Homo sapiens
N-[(3R)-1-(3-amino-4-chloro-1,2-benzoxazol-7-yl)pyrrolidin-3-yl]-2-chloro-4-(4H-1,2,4-triazol-4-yl)benzamide
-
Homo sapiens
N-[(3R)-1-(3-amino-4-chloro[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(1-methyl-2-oxo-1,2-dihydropyrimidin-5-yl)benzamide
-
Homo sapiens
N-[(3R)-1-(3-amino-4-chloro[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(1-methyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)benzamide
-
Homo sapiens
N-[(3R)-1-(3-amino-4-chloro[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)benzamide
-
Homo sapiens
N-[(3R)-1-(3-amino-4-chloro[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(1H-imidazo[4,5-b]pyridin-1-yl)benzamide
-
Homo sapiens
N-[(3R)-1-(3-amino-4-chloro[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide
-
Homo sapiens
N-[(3R)-1-(3-amino-4-chloro[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(4H-1,2,4-triazol-4-yl)benzamide
-
Homo sapiens
N-[(3R)-1-(3-amino-4-chloro[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(pyrimidin-2-yl)benzamide
-
Homo sapiens
N-[(3R)-1-(3-amino-4-chloro[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(pyrimidin-5-yl)benzamide
-
Homo sapiens
N-[(3R)-1-(3-amino-4-chloro[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-[3-(difluoromethyl)-4H-1,2,4-triazol-4-yl]benzamide
-
Homo sapiens
N-[(3R)-1-(3-amino-4-chloro[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-[4-(2-hydroxyethyl)-1H-imidazol-1-yl]benzamide
-
Homo sapiens
N-[(3R)-1-(3-amino-4-chloro[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-4-(1H-benzimidazol-1-yl)-2-chlorobenzamide
-
Homo sapiens
N-[(3R)-1-(3-amino-4-fluoro-1,2-benzoxazol-7-yl)pyrrolidin-3-yl]-2-chloro-4-(4H-1,2,4-triazol-4-yl)benzamide
-
Homo sapiens
N-[(3R)-1-(3-amino-5-methyl[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(4H-1,2,4-triazol-4-yl)benzamide
-
Homo sapiens
N-[1-(3-amino-1,2-benzoxazol-7-yl)pyrrolidin-3-yl]-2-chloro-4-(4H-1,2,4-triazol-4-yl)benzamide
-
Homo sapiens
N-[1-(3-amino-5-methyl-1,2-benzoxazol-7-yl)pyrrolidin-3-yl]-2-chloro-4-(4H-1,2,4-triazol-4-yl)benzamide
-
Homo sapiens
N-[1-(3-amino[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(4H-1,2,4-triazol-4-yl)benzamide
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ 5 mM used in assay conditions Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P00740
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Spectrofluor FIXa + H2O i.e. (methylsulfonyl)-D-cyclohexylglycine-Gly-Arg-7-amido-4-methylcoumarin Homo sapiens (methylsulfonyl)-D-cyclohexylglycine-Gly-Arg + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
FIXa
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000013
-
at pH 8.0 and 25┬░C Homo sapiens N-[(3R)-1-(3-amino-4-chloro[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(1H-imidazo[4,5-b]pyridin-1-yl)benzamide
0.000013
-
at pH 8.0 and 25┬░C Homo sapiens N-[(3R)-1-(3-amino-4-chloro[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-[4-(2-hydroxyethyl)-1H-imidazol-1-yl]benzamide
0.000015
-
at pH 8.0 and 25┬░C Homo sapiens N-[(3R)-1-(3-amino-4-chloro[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(1-methyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)benzamide
0.000018
-
at pH 8.0 and 25┬░C Homo sapiens N-[(3R)-1-(3-amino-4-chloro[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)benzamide
0.000018
-
at pH 8.0 and 25┬░C Homo sapiens N-[1-(3-amino-5-methyl-1,2-benzoxazol-7-yl)pyrrolidin-3-yl]-2-chloro-4-(4H-1,2,4-triazol-4-yl)benzamide
0.000026
-
at pH 8.0 and 25┬░C Homo sapiens N-[(3R)-1-(3-amino-4-chloro[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(pyrimidin-5-yl)benzamide
0.000031
-
at pH 8.0 and 25┬░C Homo sapiens N-[(3R)-1-(3-amino-4-chloro[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(4H-1,2,4-triazol-4-yl)benzamide
0.000032
-
at pH 8.0 and 25┬░C Homo sapiens N-[(3R)-1-(3-amino-4-chloro-1,2-benzoxazol-7-yl)pyrrolidin-3-yl]-2-chloro-4-(4H-1,2,4-triazol-4-yl)benzamide
0.000032
-
at pH 8.0 and 25┬░C Homo sapiens N-[(3R)-1-(3-amino-4-chloro[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-4-(1H-benzimidazol-1-yl)-2-chlorobenzamide
0.000033
-
at pH 8.0 and 25┬░C Homo sapiens N-[(3R)-1-(3-amino-4-chloro[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide
0.000036
-
at pH 8.0 and 25┬░C Homo sapiens N-[(3R)-1-(3-amino-4-chloro[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(1-methyl-2-oxo-1,2-dihydropyrimidin-5-yl)benzamide
0.000041
-
at pH 8.0 and 25┬░C Homo sapiens N-[(3R)-1-(3-amino-5-methyl[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(4H-1,2,4-triazol-4-yl)benzamide
0.000045
-
at pH 8.0 and 25┬░C Homo sapiens N-[(3R)-1-(3-amino-4-chloro[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-[3-(difluoromethyl)-4H-1,2,4-triazol-4-yl]benzamide
0.000047
-
at pH 8.0 and 25┬░C Homo sapiens N-[(3R)-1-(3-amino-4,5-dichloro-1,2-benzoxazol-7-yl)pyrrolidin-3-yl]-2-chloro-4-(4H-1,2,4-triazol-4-yl)benzamide
0.00005
-
at pH 8.0 and 25┬░C Homo sapiens N-[1-(3-amino-5-methyl-1,2-benzoxazol-7-yl)pyrrolidin-3-yl]-2-chloro-4-(4H-1,2,4-triazol-4-yl)benzamide
0.000062
-
at pH 8.0 and 25┬░C Homo sapiens N-[1-(3-amino-5-methyl-1,2-benzoxazol-7-yl)pyrrolidin-3-yl]-2-chloro-4-(4H-1,2,4-triazol-4-yl)benzamide
0.000089
-
at pH 8.0 and 25┬░C Homo sapiens N-[1-(3-amino[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(4H-1,2,4-triazol-4-yl)benzamide
0.000098
-
at pH 8.0 and 25┬░C Homo sapiens N-[1-(3-amino-1,2-benzoxazol-7-yl)pyrrolidin-3-yl]-2-chloro-4-(4H-1,2,4-triazol-4-yl)benzamide
0.000172
-
at pH 8.0 and 25┬░C Homo sapiens N-[(3R)-1-(3-amino-4-fluoro-1,2-benzoxazol-7-yl)pyrrolidin-3-yl]-2-chloro-4-(4H-1,2,4-triazol-4-yl)benzamide
0.0022
-
at pH 8.0 and 25┬░C Homo sapiens 2-chloro-N-[3-methyl-1-(4-methyl-2-nitrophenyl)pyrrolidin-3-yl]-4-(4H-1,2,4-triazol-4-yl)benzamide
0.003
-
IC50 above 0.003 mM, at pH 8.0 and 25┬░C Homo sapiens N-[(3R)-1-(3-amino-4-chloro[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(pyrimidin-2-yl)benzamide