Literature summary for 3.4.21.22 extracted from

Geng, Y.; Verhamme, I.M.; Messer, A.; Sun, M.F.; Smith, S.B.; Bajaj, S.P.; Gailani, D.
A sequential mechanism for exosite-mediated factor IX activation by factor XIa (2012), J. Biol. Chem., 287, 38200-38209.

Activating Compound

Activating Compound	Comment	Organism	Structure
Factor XIa	factor XIa proteolytically activates factor IX by an exosite- and Ca2+-mediated release-rebind mechanism. XIa cleaves IX after Arg145, forming IXalpha, and then after Arg180, forming IXabeta	Homo sapiens

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms	Comment	Organism
factor IXa	-	Homo sapiens
FIXa	-	Homo sapiens

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Release 2023.1 (January 2023)