Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Factor VIIIa | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21 Star (DE3) cells | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
hanging drop vapor diffusion method, using 0.25 M ammonium acetate, 19.5% (w/v) PEG 3350 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
antithrombin | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | factor IXa contains a high-affinity Ca2+-binding site | Homo sapiens | |
additional information | factor IXa is not a Na+-binding protease | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Factor X + H2O | Homo sapiens | - |
Factor Xa + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00740 | - |
- |
Purification (Comment) | Organism |
---|---|
heparin Sepharose column chromatography and Q Sepharose column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Factor X + H2O | - |
Homo sapiens | Factor Xa + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
factor IXa | - |
Homo sapiens |
FIXa | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | factor IXa deficiency results in hemophilia | Homo sapiens |
physiological function | factor IXa is a critical enzyme for the formation of stable blood clots | Homo sapiens |