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Literature summary for 3.4.21.22 extracted from

  • Bajaj, S.P.; Schmidt, A.E.; Mathur, A.; Padmanabhan, K.; Zhong, D.; Mastri, M.; Fay, P.J.
    Factor IXa:factor VIIIa interaction. helix 330-338 of factor ixa interacts with residues 558-565 and spatially adjacent regions of the a2 subunit of factor VIIIa (2001), J. Biol. Chem., 276, 16302-16309.
    View publication on PubMed
Search for more literature for 3.4.21.22

Activating Compound

Activating Compound Comment Organism Structure
Factor VIIIa stoichoimetric complex with factor IXa, helix 330 of factor IXa interacts with the 558-565 region of factor VIII A2 subunit Homo sapiens
phospholipid membrane
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
R333Q activation of factor X is not impaired Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00063
-
 Factor X in the presence of 0.1 mM phospholipid and 5 mM Ca2+ Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ for proper binding of factor IXa to phospholipid and factor VIIIa, all of the Ca2+-sites in factor IXa must be filled Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor X + H2O Homo sapiens
-
 factor Xa
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P00740
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor X + H2O
-
 Homo sapiens factor Xa
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.001
-
 Factor X in the presence of 0.1 mM phospholipid and 5 mM Ca2+ Homo sapiens