Literature summary for 3.4.21.21 extracted from

Banner, D.W.; D'Arcy, A.; Chene, C.; Winkler, F.K.; Guha, A.; Konigsberg, W.H.; Nemerson, Y.; Kirchhofer, D.
The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor (1996), Nature, 380, 41-46.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
crystal structure at 2.0 A resolution of active-site-inhibited factor VIIa complexed with the cleaved extracellular domain of tissue factor	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	blood coagulation is initiated when tissue factor binds to coagulation factor VII to give an enzymatically active complex which then activates factors IX and X, leading to thrombin generation and clot formation	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	blood coagulation is initiated when tissue factor binds to coagulation factor VII to give an enzymatically active complex which then activates factors IX and X, leading to thrombin generation and clot formation	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)