Activating Compound | Comment | Organism | Structure |
---|---|---|---|
tissue factor | tissue factor facilitates the activation of the enzyme | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor IX + H2O | Homo sapiens | - |
factor IXa + ? | - |
? | |
Factor X + H2O | Homo sapiens | - |
Factor Xa + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood vessel | - |
Homo sapiens | - |
heart | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor IX + H2O | - |
Homo sapiens | factor IXa + ? | - |
? | |
Factor X + H2O | - |
Homo sapiens | Factor Xa + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FVIIa | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | tissue factor facilitates the activation of the enzyme thereby initiating the extrinsic coagulation pathway followed by the activation of factor X and thrombin formation. The enzyme functions in blood coagulation and maintenance of the hemostatic balance in the vasculature. The tissue factor:factor VIIa complex is one of the triggers of PAR-2 activation. The tissue factor:factorVIIa pathway is also implicated in the onset of cardiac fibrosis | Homo sapiens |