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Literature summary for 3.4.21.21 extracted from

  • Eriksson, O.; Thulin, A.; Asplund, A.; Hegde, G.; Navani, S.; Siegbahn, A.
    Cross-talk between the tissue factor/coagulation factor VIIa complex and the tyrosine kinase receptor EphA2 in cancer (2016), BMC Cancer, 16, 341 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Factor X + H2O Homo sapiens
-
 Factor Xa + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MDA-MB-231 cell
-
 Homo sapiens
-
U-251MG cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Factor X + H2O
-
 Homo sapiens Factor Xa + ?
-
 ?

Synonyms

Synonyms Comment Organism
FVIIa
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function tissue factor/coagulation factor VIIa-EphA2 cross-talk potentiates ligand-dependent EphA2 signaling in human cancers. Tissue factor and EphA2 co-localize constitutively in MDA-MB-231 cells, and addition of enzyme results in cleavage of EphA2 by a protease activated receptor 2-independent mechanism Homo sapiens