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Literature summary for 3.4.21.21 extracted from

  • Margaritis, P.; Roy, E.; Faella, A.; Downey, H.D.; Ivanciu, L.; Pavani, G.; Zhou, S.; Bunte, R.M.; High, K.A.
    Catalytic domain modification and viral gene delivery of activated factor VII confers hemostasis at reduced expression levels and vector doses in vivo (2011), Blood, 117, 3974-3982.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine gene-based FVIIa variants show improved hemostatic efficacy for the treatment of hemophilia. Factor VIIa variants VEAY7 and DVQ30 exhibit increased tissue factor-independent coagulant activity relative to the wild type Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Synonyms

Synonyms Comment Organism
activated factor VII
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Mus musculus
FVIIa
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Mus musculus