Activating Compound | Comment | Organism | Structure |
---|---|---|---|
tissue factor | TF, complex formation with factor VIIa, structure, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E154R | site-directed mutagenesis, activity and active site structure in comparison to the wild-type | Homo sapiens |
E296R | site-directed mutagenesis, activity and active site structure in comparison to the wild-type | Homo sapiens |
K192Q | site-directed mutagenesis, activity and active site structure in comparison to the wild-type | Homo sapiens |
K341Q | site-directed mutagenesis, activity and active site structure in comparison to the wild-type | Homo sapiens |
M156K | site-directed mutagenesis, activity and active site structure in comparison to the wild-type | Homo sapiens |
M156Q | site-directed mutagenesis, activity and active site structure in comparison to the wild-type | Homo sapiens |
M298K | site-directed mutagenesis, activity and active site structure in comparison to the wild-type | Homo sapiens |
M298Q | site-directed mutagenesis, activity and active site structure in comparison to the wild-type | Homo sapiens |
Q143R | site-directed mutagenesis, activity and active site structure in comparison to the wild-type | Homo sapiens |
Q176G | site-directed mutagenesis, activity and active site structure in comparison to the wild-type | Homo sapiens |
Q286R | site-directed mutagenesis, activity and active site structure in comparison to the wild-type | Homo sapiens |
Q40G | site-directed mutagenesis, activity and active site structure in comparison to the wild-type | Homo sapiens |
T151Q | site-directed mutagenesis, activity and active site structure in comparison to the wild-type | Homo sapiens |
T293Q | site-directed mutagenesis, activity and active site structure in comparison to the wild-type | Homo sapiens |
V158E | site-directed mutagenesis, activity and active site structure in comparison to the wild-type | Homo sapiens |
V21E | site-directed mutagenesis, activity and active site structure in comparison to the wild-type | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
antithrombin | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | binding structure | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor IX + H2O | Homo sapiens | - |
factor IXa + ? | - |
? | |
Factor X + H2O | Homo sapiens | - |
Factor Xa + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
substrate specificity of wild-type and mutant enzymes | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzyloxycarbonyl-D-Arg-Gly-Arg-4-nitroanilide + H2O | chromogenic S-2765 | Homo sapiens | ? | - |
? | |
D-Ile-Pro-Arg-4-nitroanilide + H2O | chromogenic substrate S-2288 | Homo sapiens | D-Ile-Pro-Arg + 4-nitroaniline | - |
? | |
factor IX + H2O | - |
Homo sapiens | factor IXa + ? | - |
? | |
Factor X + H2O | - |
Homo sapiens | Factor Xa + ? | - |
? | |
Factor X + H2O | macromolecular substrate interactions at exosites, sites within the FVIIa-TF complex distant from the active site of FVIIa, determine affinity and specificity in the productive recognition of FX | Homo sapiens | Factor Xa + ? | - |
? | |
additional information | a loop of factor VIIa influences the macromolecular substrate specificity, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FVIIa | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |