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Literature summary for 3.4.21.21 extracted from
- Hemextin AB complex, a unique anticoagulant protein complex from Hemachatus haemachatus (African Ringhals cobra) venom that inhibits clot initiation and factor VIIa activity (2005), J. Biol. Chem., 280, 42601-42611.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| hemextin A | 0.05 mM, 70% inhibition | Homo sapiens | |
| hemextin AB complex | IC50: 100 nM | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzyloxycarbonyl-D-arginyl-glycyl-L-arginyl-p-nitroanilide + H2O | - |
Homo sapiens | benzyloxycarbonyl-D-arginyl-glycyl-L-arginine + p-nitroaniline | - |
? |  |
| factor X + H2O | - |
Homo sapiens | factor Xa | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| factor VIIa-sTF | - |
Homo sapiens |
| factor VIIa-TF | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0001 | - |
IC50: 100 nM | Homo sapiens | hemextin AB complex |
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Release 2023.1 (January 2023)
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