Protein Variants | Comment | Organism |
---|---|---|
H216A | mutant enzyme with decreased sensitivity to Zn2+ inhibition | Homo sapiens |
H257A | mutant enzyme with decreased sensitivity to Zn2+ inhibition | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | two Zn2+ bind with high affinity to factor VIIa outside the N-terminal gamma-carboxyglutamic acid domain. Binding of Zn2+ is influenced by presence of Ca2+ and results in decreased amidolytic activity and slightly reduced affinity for tissue factor. After binding to tissue factor, factor VIIa is less susceptible to zinc inhibition | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-Ile-Pro-Arg-p-nitroanilide + H2O | i.e. S2288 | Homo sapiens | D-Ile-Pro-Arg + p-nitroaniline | - |
? |