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Literature summary for 3.4.21.21 extracted from

  • Petersen, L.C.; Olsen, O.H.; Nielsen, L.S.; Freskgard, P.O.; Persson, E.
    Binding of Zn2+ to a Ca2+ loop allosterically attenuates the activity of factor VIIa and reduces its affinity for tissue factor (2000), Protein Sci., 9, 859-866.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
H216A mutant enzyme with decreased sensitivity to Zn2+ inhibition Homo sapiens
H257A mutant enzyme with decreased sensitivity to Zn2+ inhibition Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Zn2+ two Zn2+ bind with high affinity to factor VIIa outside the N-terminal gamma-carboxyglutamic acid domain. Binding of Zn2+ is influenced by presence of Ca2+ and results in decreased amidolytic activity and slightly reduced affinity for tissue factor. After binding to tissue factor, factor VIIa is less susceptible to zinc inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Ile-Pro-Arg-p-nitroanilide + H2O i.e. S2288 Homo sapiens D-Ile-Pro-Arg + p-nitroaniline
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