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Literature summary for 3.4.21.20 extracted from

  • Eipper, S.; Steiner, R.; Lesner, A.; Sienczyk, M.; Palesch, D.; Halatsch, M.E.; Zaczynska, E.; Heim, C.; Hartmann, M.D.; Zimecki, M.; Wirtz, C.R.; Burster, T.
    Lactoferrin is an allosteric enhancer of the proteolytic activity of cathepsin G (2016), PLoS ONE, 11, e0151509 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.20

Activating Compound

Activating Compound Comment Organism Structure
lactoferrin allosteric enhancer of the proteolytic activity of the enzyme with highest enhancing capacity under acidic (pH 5.0) conditions at 0.0025-0.25 mg/ml Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-(((S)-3-methyl-1-((S)-2-(((S)-1-((4-nitrophenyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamoyl)pyrrolidin-1-yl)-1-oxobutan-2-yl)amino)-4-oxobutanoic acid + H2O
-
 Homo sapiens ?
-
 ?
MARS116 + H2O i.e. diphenyl(1-((S)-1-((4-oxo-4-((5-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)pentyl)amino)butanoyl)-L-valyl)pyrrolidine-2-carboxamido)-2-phenylethyl)phosphonate. The reaction occurs in the presence of lactoferrin only Homo sapiens ?
-
 ?
MARS123 + H2O i.e. bis(4-methoxyphenyl) (1-((S)-1-((5-((3aS,4S,6aR)-3a,6a-dimethyl-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoyl)-L-valyl)pyrrolidine-2-carboxamido)-3-methylbutyl)phosphonate. The reaction occurs in the presence of lactoferrin only Homo sapiens ?
-
 ?
MARS125 + H2O i.e. diphenyl(1-((S)-1-((5-((3aS,4S,6aR)-3a,6adimethyl-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoyl)-L-valyl)pyrrolidine-2-carboxamido)-2-methylpropyl)phosphonate. The reaction occurs in the presence of lactoferrin only Homo sapiens ?
-
 ?
additional information lactoferrin is not proteolytically degraded by the enzyme Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 28500, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
CatG
-
 Homo sapiens