Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.20 extracted from

  • Faraday, N.; Schunke, K.; Saleem, S.; Fu, J.; Wang, B.; Zhang, J.; Morrell, C.; Dore, S.
    Cathepsin G-dependent modulation of platelet thrombus formation in vivo by blood neutrophils (2013), PLoS ONE, 8, e71447.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.20

Inhibitors

Inhibitors Comment Organism Structure
cathepsin G inhibitor I
-
 Homo sapiens
cathepsin G inhibitor I
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cadherin + H2O Homo sapiens
-
 ?
-
 ?
cadherin + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P08311
-
-
Mus musculus P28293
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
 Homo sapiens
-
neutrophil
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cadherin + H2O
-
 Homo sapiens ?
-
 ?
cadherin + H2O
-
 Mus musculus ?
-
 ?

General Information

General Information Comment Organism
malfunction both pharmacologic inhibition of cathepsin G and its congenital absence prolonge the time for platelet thrombus to form in ferric chloride-injured mouse mesenteric arterioles. In a vaso-occlusive model of ischemic stroke, inhibition of cathepsin G and its congenital absence improves cerebral blood flow, reduces histologic brain injury, and improves neurobehavioral outcome Mus musculus
physiological function neutrophil cathepsin G is a physiologic modulator of platelet thrombus formation in vivo Homo sapiens
physiological function neutrophil cathepsin G is a physiologic modulator of platelet thrombus formation in vivo Mus musculus