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Literature summary for 3.4.21.20 extracted from

  • Wilson, T.J.; Nannuru, K.C.; Futakuchi, M.; Sadanandam, A.; Singh, R.K.
    Cathepsin G enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-kappaB ligand (2008), Cancer Res., 68, 5803-5811.
    View publication on PubMed

Application

Application Comment Organism
medicine cathepsin G is a potentially novel therapeutic target in the treatment of breast cancer bone metastasis Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
Na-tosyl-Phe-chloromethylketone effectively inhibited the action of cathepsin G against the substrate at a concentration of 1 mmol/l Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus enzyme enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-KB ligand. It is significantly up-regulated at the tumor-bone interface and is capable of generating sRANKL, which potentially enhances osteoclast activation and osteolysis ?
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?
additional information Mus musculus BALB/c enzyme enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-KB ligand. It is significantly up-regulated at the tumor-bone interface and is capable of generating sRANKL, which potentially enhances osteoclast activation and osteolysis ?
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?

Organism

Organism UniProt Comment Textmining
Mus musculus
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Balb/c mice
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Mus musculus BALB/c
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Balb/c mice
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Source Tissue

Source Tissue Comment Organism Textmining
4T1 cell murine breast adenocarcinoma cell line Mus musculus
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Cl-66 cell murine breast adenocarcinoma cell line Mus musculus
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Cl-66M2 cell murine breast adenocarcinoma cell line Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-KB ligand. It is significantly up-regulated at the tumor-bone interface and is capable of generating sRANKL, which potentially enhances osteoclast activation and osteolysis Mus musculus ?
-
?
additional information enzyme enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-KB ligand. It is significantly up-regulated at the tumor-bone interface and is capable of generating sRANKL, which potentially enhances osteoclast activation and osteolysis Mus musculus BALB/c ?
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
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Mus musculus N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
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Mus musculus BALB/c N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
?

Synonyms

Synonyms Comment Organism
cathepsin G
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Mus musculus