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Literature summary for 3.4.21.20 extracted from

  • Rafiq, K.; Hanscom, M.; Valerie, K.; Steinberg, S.F.; Sabri, A.
    Novel mode for neutrophil protease cathepsin G-mediated signaling: membrane shedding of epidermal growth factor is required for cardiomyocyte anoikis (2008), Circ. Res., 102, 32-41.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the neutrophil-derived serine protease cathepsin G induces neonatal cardiomyocyte detachment and apoptosis by anoikis, which requires matrix metalloproteinase-dependent membrane shredding of epidermal growth factor, signaling induction by the enzyme via epidermal growth factor receptor induction and transactivation, mechanism, overview ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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neonatal Sprague-Dawley rats
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Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte
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Rattus norvegicus
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heart
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Rattus norvegicus
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myocyte
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Rattus norvegicus
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neutrophil
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Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the neutrophil-derived serine protease cathepsin G induces neonatal cardiomyocyte detachment and apoptosis by anoikis, which requires matrix metalloproteinase-dependent membrane shredding of epidermal growth factor, signaling induction by the enzyme via epidermal growth factor receptor induction and transactivation, mechanism, overview Rattus norvegicus ?
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Synonyms

Synonyms Comment Organism
Cat.G
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Rattus norvegicus