Literature summary for 3.4.21.20 extracted from

Stefansson, S.; Yepes, M.; Gorlatova, N.; Day, D.E.; Moore, E.G.; Zabaleta, A.; McMahon, G.A.; Lawrence, D.A.
Mutants of plasminogen activator inhibitor-1 designed to inhibit neutrophil elastase and cathepsin G are more effective in vivo than their endogenous inhibitors (2004), J. Biol. Chem., 279, 29981-29987.

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Inhibitors

Inhibitors	Comment	Organism	Structure
alpha-1 proteinase inhibitor	-	Homo sapiens
alpha-1-antichymotrypsin	-	Homo sapiens
additional information	no inhibition by plasminogen activator inhibitor-1	Homo sapiens
mutant R346F of plasminogen activator inhibitor-1	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neutrophil	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O	-	Homo sapiens	N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0071	-	alpha-1 proteinase inhibitor	-	Homo sapiens
0.027	-	alpha-1-antichymotrypsin	-	Homo sapiens
0.59	-	mutant R346F of plasminogen activator inhibitor-1	-	Homo sapiens

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Release 2023.1 (January 2023)