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Literature summary for 3.4.21.20 extracted from

  • Selim, T.E.; Ghoneim, H.R.; Abdel Ghaffar, H.A.; Colman, R.W.; Dela Cadena, R.A.
    High molecular mass kininogen inhibits cathepsin G-induced platelet activation by forming a complex with cathepsin G (2001), Hematol. J., 2, 371-377.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
high molecular mass kininogen i.e. HK, human, competitive, inhibits platelet activation by the enzyme completely by complex formation with the enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
high molecular mass kininogen + H2O human, 120 kDa Homo sapiens peptide fragments after 1 min reaction: 110, 100, and 75 kDa fragments, after 5 min reaction: 10 to 70 kDa fragments, after 60 min: less than 20 kDa fragments ?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O chromogenic substrate Homo sapiens N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
cleavage of high molecular mass kininogen Homo sapiens