Inhibitors | Comment | Organism | Structure |
---|---|---|---|
high molecular mass kininogen | i.e. HK, human, competitive, inhibits platelet activation by the enzyme completely by complex formation with the enzyme | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
high molecular mass kininogen + H2O | human, 120 kDa | Homo sapiens | peptide fragments | after 1 min reaction: 110, 100, and 75 kDa fragments, after 5 min reaction: 10 to 70 kDa fragments, after 60 min: less than 20 kDa fragments | ? | |
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O | chromogenic substrate | Homo sapiens | N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
cleavage of high molecular mass kininogen | Homo sapiens |