Literature summary for 3.4.21.20 extracted from

Gutschow, M.; Kuerschner, L.; Pietsch, M.; Ambrozak, A.; Neumann, U.; Gunther, R.; Hofmann, H.J.
Inhibition of cathepsin G by 2-amino-3,1-benzoxazin-4-ones: kinetic investigations and docking studies (2002), Arch. Biochem. Biophys., 402, 180-191.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-(N-methyl)benzylamino-3,1-benzoxazin-4-one	strongest inhibition	Homo sapiens
2-amino-3,1-benzoxazin-4-ones	non-covalent complex formation, hydrophobic and basic residues at position 2, kinetics of acylation and desacylation, binding at the enzyme's active site	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

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Release 2023.1 (January 2023)