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Literature summary for 3.4.21.2 extracted from

  • Nemeth, B.C.; Hegyi, P.; Takacs, T.
    Evaluation of the pathogenic significance of the novel p.T58M chymotrypsin C variant in recurrent acute pancreatitis (2019), Pancreas, 48, E12-E14 .
    View publication on PubMed
Search for more literature for 3.4.21.2

Protein Variants

Protein Variants Comment Organism
T58M mutation in a late-onset case of recurrent acute pancreatitis. The T58M mutant chymotrypsin C has comparable biochemical characteristics to wild type enzyme on large substrates Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0105
-
 N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide mutant enzyme T58M, pH and temperature not specified in the publication Homo sapiens
0.0134
-
 N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide wild-type enzyme, pH and temperature not specified in the publication Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q99895
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-casein + H2O
-
 Homo sapiens ?
-
 ?
human cationic trypsinogen + H2O
-
 Homo sapiens ?
-
 ?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
-
 Homo sapiens N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
CTRC
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
11.7
-
 N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide wild-type enzyme, pH and temperature not specified in the publication Homo sapiens
24
-
 N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide mutant enzyme T58M, pH and temperature not specified in the publication Homo sapiens