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Literature summary for 3.4.21.2 extracted from
- Tighter control by chymotrypsin C (CTRC) explains lack of association between human anionic trypsinogen and hereditary pancreatitis (2016), J. Biol. Chem., 291, 12897-12905 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| anionic trypsinogen + H2O | Homo sapiens | - |
? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q99895 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| anionic trypsinogen + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| chymotrypsin C | - |
Homo sapiens |
| CTRC | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | the protective effect of chymotrypsin C against pancreatitis can be compromised by loss-of-function mutations in CTRC, which increase risk for sporadic chronic pancreatitis | Homo sapiens |
| physiological function | intrapancreatic activation of human anionic trypsinogen is prevented through chymotrypsin-mediated degradation. Chymotrypsin C controls activation of human cationic trypsinogen through proteolytic cleavage of regulatory sites. Chymotrypsin C promotes degradation of anionic trypsinogen more effectively than it does with cationic trypsinogen | Homo sapiens |
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