Cloned (Comment) | Organism |
---|---|
gene OVCH2, DNA and amino acid sequence determination and analysis | Rhinella arenarum |
gene OVCH2, DNA and amino acid sequence determination and analysis | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Rhinella arenarum | - |
- |
extracellular | - |
Mus musculus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q7M761 | gene Ovch2 | - |
Mus musculus BALB/c | Q7M761 | gene Ovch2 | - |
Rhinella arenarum | Q66TN7 | i.e. Rhinella arenarum, collected in Tucumán, Argentina, between May and October and housed at 25°C until used, gene OVCH2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | analysis of ovochymase 2 expression in the mouse reproductive tract, no expression in the oviduct | Mus musculus | - |
additional information | tissue expression analysis of oviductin | Rhinella arenarum | - |
oviduct | pars recta portion of the oviduct | Rhinella arenarum | - |
oviductal fluid | - |
Rhinella arenarum | - |
uterus | - |
Mus musculus | - |
Subunits | Comment | Organism |
---|---|---|
More | oviductin is a multi-domain protein with a protease domain at the N-terminal region followed by two CUB domains and toward the C-terminal region another protease domain, which lacks an active histidine site, and one CUB domain | Rhinella arenarum |
Synonyms | Comment | Organism |
---|---|---|
ovochymase 2 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
evolution | phylogenetic relationship between Bufo arenarum oviductin and Mus musculus ovochymase 2, overview | Rhinella arenarum |
evolution | phylogenetic relationship between Bufo arenarum oviductin and Mus musculus ovochymase 2, overview. Protease gene families involved in reproduction and host defense played a role during the evolution of some mammalian species. Thus, the absence of ovochymase 2 RNA transcripts in oviduct might be one of the signs of the transition from a primitive fertilization mode (external fertilization) to a more complex form (internal fertilization) | Mus musculus |
physiological function | oviductin, a serine protease with trypsin-like substrate specificity, hydrolyzes two kinds of egg envelope glycoproteins, gp84 and gp55, in the pars recta portion of the oviduct, thereby converting the egg to a penetrable state | Rhinella arenarum |
physiological function | ovochymase 2 might produce proteolytic changes in the zona pellucida similar to the action of amphibian oviductin, which can play a role in embryo attachment to the uterine wall during implantation | Mus musculus |