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Literature summary for 3.4.21.120 extracted from

  • Barrera, D.; Valdecantos, P.; Garci­a, E.; Miceli, D.
    Cloning and sequence analysis of Bufo arenarum oviductin cDNA and detection of its orthologous gene expression in the mouse female reproductive tract (2012), Zygote, 20, 17-26.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene OVCH2, DNA and amino acid sequence determination and analysis Rhinella arenarum
gene OVCH2, DNA and amino acid sequence determination and analysis Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Rhinella arenarum
-
-
extracellular
-
Mus musculus
-
-

Organism

Organism UniProt Comment Textmining
Mus musculus Q7M761 gene Ovch2
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Mus musculus BALB/c Q7M761 gene Ovch2
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Rhinella arenarum Q66TN7 i.e. Rhinella arenarum, collected in Tucumán, Argentina, between May and October and housed at 25°C until used, gene OVCH2
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information analysis of ovochymase 2 expression in the mouse reproductive tract, no expression in the oviduct Mus musculus
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additional information tissue expression analysis of oviductin Rhinella arenarum
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oviduct pars recta portion of the oviduct Rhinella arenarum
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oviductal fluid
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Rhinella arenarum
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uterus
-
Mus musculus
-

Subunits

Subunits Comment Organism
More oviductin is a multi-domain protein with a protease domain at the N-terminal region followed by two CUB domains and toward the C-terminal region another protease domain, which lacks an active histidine site, and one CUB domain Rhinella arenarum

Synonyms

Synonyms Comment Organism
ovochymase 2
-
Mus musculus

General Information

General Information Comment Organism
evolution phylogenetic relationship between Bufo arenarum oviductin and Mus musculus ovochymase 2, overview Rhinella arenarum
evolution phylogenetic relationship between Bufo arenarum oviductin and Mus musculus ovochymase 2, overview. Protease gene families involved in reproduction and host defense played a role during the evolution of some mammalian species. Thus, the absence of ovochymase 2 RNA transcripts in oviduct might be one of the signs of the transition from a primitive fertilization mode (external fertilization) to a more complex form (internal fertilization) Mus musculus
physiological function oviductin, a serine protease with trypsin-like substrate specificity, hydrolyzes two kinds of egg envelope glycoproteins, gp84 and gp55, in the pars recta portion of the oviduct, thereby converting the egg to a penetrable state Rhinella arenarum
physiological function ovochymase 2 might produce proteolytic changes in the zona pellucida similar to the action of amphibian oviductin, which can play a role in embryo attachment to the uterine wall during implantation Mus musculus