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Literature summary for 3.4.21.119 extracted from

  • Yousef G.M.; Chang A.; Diamandis E.P.
    Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues (2000), J. Biol. Chem., 275, 11891-11898.
    View publication on PubMed

Application

Application Comment Organism
medicine gene may be involved in the pathogenesis and/or progression of breast cancer and may find applicability as cancer biomarker Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene KLK-L4, DNA sequence determination and analysis, gene mapps to chromosome 19q13.3-q13.4, tissue expression analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
polypeptide + H2O Homo sapiens
-
peptides
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UKR3 GenBank: AF135024; kallikrein-like gene 4, i.e. KLK-L4
-

Reaction

Reaction Comment Organism Reaction ID
Hydrolyses mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg-/- pair in the N-terminus, to yield mature renin enzyme is a serine protease Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
breast
-
Homo sapiens
-
breast carcinoma cell down-regulated by steroid hormones Homo sapiens
-
additional information gene is expressed in various tissues Homo sapiens
-
prostate
-
Homo sapiens
-
salivary gland
-
Homo sapiens
-
testis
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
polypeptide + H2O
-
Homo sapiens peptides
-
?