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Literature summary for 3.4.21.119 extracted from

  • Nakayama, K.; Kim, W.S.; Hatsuzawa, K.; Hashiba, K.; Murakami, K.
    Tissue distribution and characterization of prorenin-converting enzyme in mouse (1989), Biochem. Biophys. Res. Commun., 158, 369-376.
    View publication on PubMed
Search for more literature for 3.4.21.119

Inhibitors

Inhibitors Comment Organism Structure
antipain
-
 Mus musculus
benzamidine
-
 Mus musculus
leupeptin
-
 Mus musculus
additional information little or no effect by the following protease inhibitors: PMSF, DFP, aprotinin, iodoacetamide, NEM, PCMBS, and E-64; no inhibition by EDTA and pepstatin A Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
polypeptide + H2O Mus musculus
-
 peptides
-
 ?
Prorenin + H2O Mus musculus inactive precursor Renin + ? product is an active enzyme ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 female and male ICR mice, Balb/c mice
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney low activity Mus musculus
-
additional information no activity in liver, brain, heart, and pancreas Mus musculus
-
submandibular gland highest activity Mus musculus
-
submandibular gland enzyme regulation is parallel and similar to that of renin Mus musculus
-
submandibular gland larger amounts in male than female mice Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
polypeptide + H2O
-
 Mus musculus peptides
-
 ?
polypeptide + H2O cleavage site at paired basic amino acid residues Mus musculus peptides
-
 ?
Prorenin + H2O cleavage site at paired basic amino acid residues Mus musculus Renin + ?
-
 ?
Prorenin + H2O murine or human origin substrate from Xenopus oocytes expression system Mus musculus Renin + ?
-
 ?
Prorenin + H2O inactive precursor Mus musculus Renin + ? product is an active enzyme ?

Synonyms

Synonyms Comment Organism
More enzyme is neither trypsin-like nor kallikrein Mus musculus
prorenin-converting enzyme
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8 8.5
-
 Mus musculus