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Literature summary for 3.4.21.118 extracted from
- Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation (2010), Biol. Chem., 391, 455-460.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| pefabloc | - |
Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| skin | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | KLK8 does not degrade and activate promeprin alpha | Homo sapiens | ? | - |
? | |
| additional information | KLK8 has a strong preference for Arg in P1, and Arg and Lys in P3 position and prefers hydrophobic residues in P2 and small hydrophobic residues in P4 position | Homo sapiens | ? | - |
? | |
| promeprin beta + H2O | KLK8 activates promeprin beta | Homo sapiens | meprin beta | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| KLK8 | - |
Homo sapiens |
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