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Literature summary for 3.4.21.118 extracted from

  • Lu, Z.X.; Huang, Q.; Su, B.
    Functional characterization of the human-specific (type II) form of kallikrein 8, a gene involved in learning and memory (2009), Cell Res., 19, 259-267.
    View publication on PubMed
Search for more literature for 3.4.21.118

Cloned(Commentary)

Cloned (Comment) Organism
recombinant KLK 8 type II is expressed using the baculovirus insect cell system Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-(7-amino-1-chloro-2-oxoheptan-3-yl)-4-methylbenzenesulfonamide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the extra 45 amino acids of KLK8 type II are removed during the enzyme activation process, resulting in the same end-point enzyme as that of type I Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain preferential expression of KLK8 type II Homo sapiens
-
embryo expression in embryo brain samples Homo sapiens
-
embryonic stem cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Boc-Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens ?
-
 ?
Boc-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens ?
-
 ?
Boc-Val-Pro-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
kallikrein 8 type II, human-specific splice form of KLK8 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.2
-
 assay at Homo sapiens