Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.118 extracted from

  • Ishikawa, Y.; Horii, Y.; Tamura, H.; Shiosaka, S.
    Neuropsin (KLK8)-dependent and -independent synaptic tagging in the Schaffer-collateral pathway of mouse hippocampus (2008), J. Neurosci., 28, 843-849.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information single tetanus evokes a neuropsin-dependent form that follows downstream signaling into integrin/actin signal and L-type voltage-dependent Ca2+ channel pathway. A neuropsin-independent form of synaptic capture is evoked by a stronger (two) tetanus Mus musculus

Application

Application Comment Organism
medicine occurrence of two synaptic capture mechanisms for a weakly stimulated synapse to acquire persistency (i.e., neuropsin dependent and independent). Neuropsin-dependent late associativity may serve in the acquisition of nonaversive memory (e.g., inquisitive behavior) Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information neuropsin-deficient mice, are significantly impaired in hippocampus-dependent behavioral memory. Synaptic late associativity is impaired Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
NP STOP neuropsin-specific inhibitor. Single stimulus in S1 during application of NP STOP completely eliminates the late associativity between S0 and S1 synapses. When a strong (four) stimulus in S0 is followed by the application of NP STOP, the late associativity between S0 and S1 synapses is not eliminated Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Mus musculus
-
male C57BL/6J mice
-

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
kallikrein-related peptidase 8
-
Mus musculus
KLK8
-
Mus musculus
neuropsin
-
Mus musculus