Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | single tetanus evokes a neuropsin-dependent form that follows downstream signaling into integrin/actin signal and L-type voltage-dependent Ca2+ channel pathway. A neuropsin-independent form of synaptic capture is evoked by a stronger (two) tetanus | Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | occurrence of two synaptic capture mechanisms for a weakly stimulated synapse to acquire persistency (i.e., neuropsin dependent and independent). Neuropsin-dependent late associativity may serve in the acquisition of nonaversive memory (e.g., inquisitive behavior) | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | neuropsin-deficient mice, are significantly impaired in hippocampus-dependent behavioral memory. Synaptic late associativity is impaired | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NP STOP | neuropsin-specific inhibitor. Single stimulus in S1 during application of NP STOP completely eliminates the late associativity between S0 and S1 synapses. When a strong (four) stimulus in S0 is followed by the application of NP STOP, the late associativity between S0 and S1 synapses is not eliminated | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
male C57BL/6J mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hippocampus | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
kallikrein-related peptidase 8 | - |
Mus musculus |
KLK8 | - |
Mus musculus |
neuropsin | - |
Mus musculus |