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Literature summary for 3.4.21.118 extracted from

  • Kishibe, M.; Bando, Y.; Terayama, R.; Namikawa, K.; Takahashi, H.; Hashimoto, Y.; Ishida-Yamamoto, A.; Jiang, Y.P.; Mitrovic, B.; Perez, D.; Iizuka, H.; Yoshida, S.
    Kallikrein 8 is involved in skin desquamation in cooperation with other kallikreins (2007), J. Biol. Chem., 282, 5834-5841.
    View publication on PubMed
Search for more literature for 3.4.21.118

Activating Compound

Activating Compound Comment Organism Structure
12-O-tetradecanoylphorbol-13-acetate upregulates Klk8 mRNA 5fold Mus musculus

Application

Application Comment Organism
medicine in psoriatic lesion, KLK8 modulates hyperproliferation and prevents excessive hyperkeratosis by shedding the corneocytes Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
into the expression cosmid cassette pAxCAwt as a transfer vector for adenovirus preparation, transfection into primary keratinocyte cultures from the skin of Klk8-/- mice Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information Klk8-/- mice, show less proliferation and an increase in the number of cell layers in the stratum corneum. Inefficient cleavage of adhesion molecules DSG1 and CDSN in Klk8-/- skin, which contributes to a delay in corneocyte shedding, resulting in hyperkeratosis phenotype Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6 mice
-
Mus musculus C57BL/6
-
 C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
keratinocyte
-
 Mus musculus
-
skin
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Boc-Phe-Ser-Arg-4-methylcoumarin-7-amide + H2O
-
 Mus musculus ?
-
 ?
Boc-Phe-Ser-Arg-4-methylcoumarin-7-amide + H2O
-
 Mus musculus C57BL/6 ?
-
 ?
Boc-Val-Pro-Arg-4-methylcoumarin-7-amide + H2O
-
 Mus musculus ?
-
 ?
Boc-Val-Pro-Arg-4-methylcoumarin-7-amide + H2O
-
 Mus musculus C57BL/6 ?
-
 ?
casein + H2O
-
 Mus musculus ?
-
 ?
casein + H2O
-
 Mus musculus C57BL/6 ?
-
 ?

Synonyms

Synonyms Comment Organism
hK8
-
 Mus musculus
neuropsin expressed from KLK8 Mus musculus