Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no inhibition by soybean trypsin inhibitor | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
10000 | - |
x * 10000 + x * 18000, SDS-PAGE | Rattus norvegicus |
18000 | - |
x * 10000 + x * 18000, SDS-PAGE | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
polypeptide + H2O | Rattus norvegicus | - |
peptides | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
gene KLK8 | - |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys | kallikrein k8 exhibit a marked preference for cleavage downstream of Arg residues | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
submaxillary gland | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzoyl-Phe-Val-Arg-4-methylcoumarin 7-amide + H2O | - |
Rattus norvegicus | benzoyl-Phe-Val-Arg + 7-amino-4-methylcoumarin | - |
? | |
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide + H2O | - |
Rattus norvegicus | benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin | - |
? | |
additional information | kallikrein k8 exhibits a marked preference for cleavage downstream of Arg residues | Rattus norvegicus | ? | - |
? | |
additional information | no activity with tert-butyloxycarbonyl-Leu-Gly-Arg-4-methylcoumarin 7-amide | Rattus norvegicus | ? | - |
? | |
polypeptide + H2O | - |
Rattus norvegicus | peptides | - |
? | |
Pro-Phe-Arg-4-methylcoumaryl-7-amide | - |
Rattus norvegicus | Pro-Phe-Arg + 7-amino-4-methylcoumarin | - |
? | |
tert-butyloxycarbonyl-Phe-Ser-Arg-4-methylcoumaryl-7-amide + H2O | no activity | Rattus norvegicus | tert-butyloxycarbonyl-Phe-Ser-Arg + 7-amino-4-methylcoumarin | - |
? | |
tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumaryl-7-amide + H2O | - |
Rattus norvegicus | tert-butyloxycarbonyl-Val-Pro-Arg + 7-amino-4-methylcoumarin | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 10000 + x * 18000, SDS-PAGE | Rattus norvegicus |