Literature summary for 3.4.21.118 extracted from

Matsumoto-Miyai, K.; Kitagawa, R.; Ninomiya, A.; Momota, Y.; Yoshida, S.; Shiosaka, S.
Decidualization induces the expression and activation of an extracellular protease neuropsin in mouse uterus (2002), Biol. Reprod., 67, 1414-1418.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	enzyme is induced and activated by uterine decidualization	Mus musculus

Application

Application	Comment	Organism
biotechnology	enzyme might contribute to the remodeling of extracellular components after decidualization	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	secreted	Mus musculus	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
polypeptide + H2O	Mus musculus	-	peptides	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q61955	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys	enzyme is a trypsin-type serine protease	Mus musculus	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
uterus	low activity in nonpregnant uteri, increased activity in pregnant uteri, highest at midgestational period	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
polypeptide + H2O	-	Mus musculus	peptides	-	?
tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumaryl-7-amide + H2O	-	Mus musculus	tert-butyloxycarbonyl-Val-Pro-Arg + 7-amino-4-methylcoumarin	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Mus musculus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Mus musculus

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Release 2023.1 (January 2023)