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Literature summary for 3.4.21.117 extracted from
- Human tissue kallikreins as promiscuous modulators of homeostatic skin barrier functions (2008), Biol. Chem., 389, 669-680.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| LEKTI | LEKTI is expressed in stratum corneum and in stratum granulosum and is a reversible inhibitor encoded by the SPINK5 (serine protease inhibitor Kazal type 5) gene. LEKTI is a weak inhibitor toward KLK 7 but a much stronger inhibitor toward KLK5 | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| skin | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acidic sphingomyelinase + H2O | - |
Homo sapiens | ? | - |
? | |
| beta-glucocerebrosidase + H2O | - |
Homo sapiens | ? | - |
? | |
| corneodesmosin + H2O | KLK7 degrades corneodesmosomes CDSN, DSC1, and DSG1 | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| kallikrein 7 | - |
Homo sapiens |
| KLK7 | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
enzyme shows optimal activity at neutral pH, and retains significant activity at acidic pH | Homo sapiens |
| 5.5 | - |
proteolysis of corneodesmosin | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000348 | - |
LEKTI | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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