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Literature summary for 3.4.21.117 extracted from

  • Tanimoto, H.; Underwood, L.J.; Shigemasa, K.; Yan Yan, M.S.; Clarke, J.; Parmley, T.H.; O'Brien, T.J.
    The stratum corneum chymotryptic enzyme that mediates shedding and desquamation of skin cells is highly overexpressed in ovarian tumor cells (1999), Cancer, 86, 2074-2082.
    View publication on PubMed
Search for more literature for 3.4.21.117

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme may contribute to tumor cell growth, tumor spread, and the metastatic potential of ovarian tumor cells ?
-
 ?
polypeptide + H2O Homo sapiens mediates shedding and desquamation of skin cells peptides
-
 ?
polypeptide + H2O Homo sapiens catalyzes the degradation of intercellular cohesive structures in the cornified layer of the skin in the continous sheeding of the cells from the skin surface peptides
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
cleavage of proteins with aromatic side chains in the P1 position enzyme is a chymotrypsin-like serine protease Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
additional information no activity in healthy ovary Homo sapiens
-
ovarian carcinoma cell different carcinoma cell lines and types, overview Homo sapiens
-
ovarian carcinoma cell overexpression of the enzyme Homo sapiens
-
skin
-
 Homo sapiens
-
stratum corneum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme may contribute to tumor cell growth, tumor spread, and the metastatic potential of ovarian tumor cells Homo sapiens ?
-
 ?
polypeptide + H2O
-
 Homo sapiens peptides
-
 ?
polypeptide + H2O mediates shedding and desquamation of skin cells Homo sapiens peptides
-
 ?
polypeptide + H2O catalyzes the degradation of intercellular cohesive structures in the cornified layer of the skin in the continous sheeding of the cells from the skin surface Homo sapiens peptides
-
 ?

Synonyms

Synonyms Comment Organism
SCCE
-
 Homo sapiens