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Literature summary for 3.4.21.116 extracted from

  • Ramixadrez-Guadiana, F.; Rodrigues, C.; Marquis, K.; Campo, N.; Barajas-Ornelas, R.; Brock, K.; Marks, D.; Kruse, A.; Rudner, D.
    Evidence that regulation of intramembrane proteolysis is mediated by substrate gating during sporulation in Bacillus subtilis (2018), PLoS Genet., 14, e1007753 .
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Bacillus subtilis 16020
-

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-
Bacillus subtilis PY79
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-sigmaK + H2O
-
Bacillus subtilis sigmaK + ?
-
?
pro-sigmaK + H2O
-
Bacillus subtilis PY79 sigmaK + ?
-
?

General Information

General Information Comment Organism
physiological function a stable association between the membrane-embedded protease SpoIVFB and its substrate requires SpoIVB signaling. The cytoplasmic cystathionine-beta-synthase domain of the SpoIVFB protease is not critical for this interaction or for pro-sigmaK processing. A model explains IVB-dependent cleavage of SpoIVFA on one side of the membrane triggers a conformational change in the membrane-embedded protease from a closed to an open state allowing pro-sigmaK access to the caged interior of the protease Bacillus subtilis