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Literature summary for 3.4.21.110 extracted from

  • Lynskey, N.N.; Reglinski, M.; Calay, D.; Siggins, M.K.; Mason, J.C.; Botto, M.; Sriskandan, S.
    Multi-functional mechanisms of immune evasion by the streptococcal complement inhibitor C5a peptidase (2017), PLoS Pathog., 13, e1006493 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Streptococcus pyogenes serotype M1 P58099
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C3 + H2O
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 Streptococcus pyogenes serotype M1 ?
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 ?
complement component C3a + H2O
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 Streptococcus pyogenes serotype M1 ?
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 ?

General Information

General Information Comment Organism
physiological function complement components C3 and C3a are substrates for peptidase C5a. Both are functionally inactivated as a result of cleavage 7 amino acids upstream of the natural C3 convertase. Cleavage of C3a by C5a results in disruption of human neutrophil activation, phagocytosis and chemotaxis, while cleavage of C3 generates abnormally-sized C3a and C3b moieties with impaired function, in particular reducing C3 deposition on the bacterial surface. Expression of C5a reduces clearance of group A streptococci in vivo in wild-type and C5 deficient mice, and promotes systemic bacterial dissemination in mice that lack both C3 and C5 Streptococcus pyogenes serotype M1