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BRENDA support

Literature summary for 3.4.21.110 extracted from

  • Hull, J.R.; Tamura, G.S.; Castner, D.G.
    Interactions of the streptococcal C5a peptidase with human fibronectin (2008), Acta Biomater., 4, 504-513.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information at the lowest fibronectin coverages the probability of observing a ScpB-Fn binding event increases linearly with fibronectin surface coverage. As a fibronectin monolayer is reached the probability of a ScpB-fibronectin binding event occurring increases markedly (ca. 50fold), with a concomitant increase in the rupture force from 17 pN to 33 pN Streptococcus sp.

Organism

Organism UniProt Comment Textmining
Streptococcus sp.
-
group B streptococci
-

Purification (Commentary)

Purification (Comment) Organism
as a GST fusion protein Streptococcus sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information group B Streptococci do not bind to fibronectin in solution, but bind to fibronectin adsorbed onto a solid surface through ScpB, that binds to a motif created by the juxtaposition of multiple fibronectin molecules Streptococcus sp. ?
-
?

Synonyms

Synonyms Comment Organism
ScpB
-
Streptococcus sp.