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Literature summary for 3.4.21.109 extracted from
- Conserved function of the matriptase-prostasin proteolytic cascade during epithelial morphogenesis (2019), PLoS Genet., 15, e1007882 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | A1Z7M3 | isoform A | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dumpy + H2O | i.e. a zona pellucida-domain protein | Drosophila melanogaster | ? | - |
? |  |
| tracheal-prostasin zymogen + H2O | - |
Drosophila melanogaster | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| notopleural | - |
Drosophila melanogaster |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | notopleural is a functional homologue of matriptase. Notopleural mediates morphogeneisis and remodeling of apical extracellular matrix during tracheal system development and is essential for maintenance of the transepithelial barrier function. Notopleural degrades the zona pellucida-domain protein Dumpy, a component of the transient tracheal apical extracellular matrix. Notopleural cleaves tracheal-prostasin zymogen and the zona pellucida-domain of the extracellular matrix protein Piopio in vitro | Drosophila melanogaster |
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Release 2023.1 (January 2023)
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