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Literature summary for 3.4.21.109 extracted from

  • Bergum, C.; Zoratti, G.; Boerner, J.; List, K.
    Strong expression association between matriptase and its substrate prostasin in breast cancer (2012), J. Cell. Physiol., 227, 1604-1609.
    View publication on PubMed
Search for more literature for 3.4.21.109

Protein Variants

Protein Variants Comment Organism
additional information siRNA knockdown of the enzyme in MCF-7 cells using three independent non-overlapping synthetic RNA duplexes Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane a membrane anchored serine protease Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
 x * 70000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-form GPI-anchored serine protease prostasin + H2O Homo sapiens activation, prostasin is also a regulator of the epidermal sodium channel like matriptase mature GPI-anchored serine protease prostasin + ?
-
 ?
pro-form matriptase + H2O Homo sapiens autocatalytic activation mature matriptase + ?
-
 ?
prostasin + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens Q9Y5Y6
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the enzyme performs autocatalytic activation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
breast co-expression of matriptase and its substrate serine protease prostasin Homo sapiens
-
breast cancer cell
-
 Homo sapiens
-
breast cancer cell strong expression association between matriptase and its substrate prostasin in breast cancer Homo sapiens
-
BT-20 cell
-
 Homo sapiens
-
BT-474 cell
-
 Homo sapiens
-
epithelium matriptase and prostasin display a near identical spatial expression pattern in the epithelial compartment of breast cancer tissue Homo sapiens
-
HCC-1937 cell
-
 Homo sapiens
-
HCC-1954 cell
-
 Homo sapiens
-
MCF-10A cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-468 cell
-
 Homo sapiens
-
additional information not detected in MDA-MB-231, SUM1315, BT-549, and SUM-159 cells Homo sapiens
-
additional information expression of matriptase and prostasin in breast cancer cell lines, overview. No activity in MDA-MB-231 cells, SUM-159 cells, SUM-1315cells, and BT-549 cells Homo sapiens
-
SK-BR-3 cell
-
 Homo sapiens
-
SUM-102 cell
-
 Homo sapiens
-
SUM-149 cell
-
 Homo sapiens
-
SUM-185 cell
-
 Homo sapiens
-
SUM-190 cell
-
 Homo sapiens
-
SUM-225 cell
-
 Homo sapiens
-
SUM-229 cell
-
 Homo sapiens
-
SUM-44 cell
-
 Homo sapiens
-
SUM-52 cell
-
 Homo sapiens
-
T-47D cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-form GPI-anchored serine protease prostasin + H2O activation Homo sapiens mature GPI-anchored serine protease prostasin + ?
-
 ?
pro-form GPI-anchored serine protease prostasin + H2O activation, prostasin is also a regulator of the epidermal sodium channel like matriptase Homo sapiens mature GPI-anchored serine protease prostasin + ?
-
 ?
pro-form matriptase + H2O autocatalytic activation Homo sapiens mature matriptase + ?
-
 ?
prostasin + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 70000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
epithin
-
 Homo sapiens
MT-SP1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the matriptase-prostasin cascade plays a critical role in breast cancer Homo sapiens
physiological function matriptase is a regulator of the epidermal sodium channel Homo sapiens