Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro matrix metalloproteinase 1 + H2O | Homo sapiens | matriptase activates pro-matrix metalloproteinase-1 and processes pro-matrix metalloproteinase-3 to its fully active form | ? | - |
? | |
pro matrix metalloproteinase 3 + H2O | Homo sapiens | matriptase activates pro-matrix metalloproteinase-1 and processes pro-matrix metalloproteinase-3 to its fully active form | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cartilage | amtripase gene expression in femoral head cartilage is analyzed | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro matrix metalloproteinase 1 + H2O | matriptase activates pro-matrix metalloproteinase-1 and processes pro-matrix metalloproteinase-3 to its fully active form | Homo sapiens | ? | - |
? | |
pro matrix metalloproteinase 3 + H2O | matriptase activates pro-matrix metalloproteinase-1 and processes pro-matrix metalloproteinase-3 to its fully active form | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
matriptase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | matriptase gene expression is significantly elevated in patients with osteoarthritis cartilage compared with patients with fracture to the neck of the femur cartilage | up |
General Information | Comment | Organism |
---|---|---|
physiological function | exogenous matriptase significantly enhances cytokine-stimulated cartilage collagenolysis, while matriptase alone causes significant collagenolysis from osteoarthritis cartilage, which is metalloproteinase-dependent. Matriptase also induces metalloproteinase-1, -3, -13 gene expression. Synovial perfusion data confirm that matriptase activates proteinase activated receptor-2, and matriptase-dependent enhancement of collagenolysis from osteoarthritis cartilage is blocked by proteinase activated receptor-2 inhibition | Homo sapiens |