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Literature summary for 3.4.21.109 extracted from

  • Milner, J.M.; Patel, A.; Davidson, R.K.; Swingler, T.E.; Desilets, A.; Young, D.A.; Kelso, E.B.; Donell, S.T.; Cawston, T.E.; Clark, I.M.; Ferrell, W.R.; Plevin, R.; Lockhart, J.C.; Leduc, R.; Rowan, A.D.
    Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis (2010), Arthritis Rheum., 62, 1955-1966.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro matrix metalloproteinase 1 + H2O Homo sapiens matriptase activates pro-matrix metalloproteinase-1 and processes pro-matrix metalloproteinase-3 to its fully active form ?
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?
pro matrix metalloproteinase 3 + H2O Homo sapiens matriptase activates pro-matrix metalloproteinase-1 and processes pro-matrix metalloproteinase-3 to its fully active form ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cartilage amtripase gene expression in femoral head cartilage is analyzed Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro matrix metalloproteinase 1 + H2O matriptase activates pro-matrix metalloproteinase-1 and processes pro-matrix metalloproteinase-3 to its fully active form Homo sapiens ?
-
?
pro matrix metalloproteinase 3 + H2O matriptase activates pro-matrix metalloproteinase-1 and processes pro-matrix metalloproteinase-3 to its fully active form Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
matriptase
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens matriptase gene expression is significantly elevated in patients with osteoarthritis cartilage compared with patients with fracture to the neck of the femur cartilage up

General Information

General Information Comment Organism
physiological function exogenous matriptase significantly enhances cytokine-stimulated cartilage collagenolysis, while matriptase alone causes significant collagenolysis from osteoarthritis cartilage, which is metalloproteinase-dependent. Matriptase also induces metalloproteinase-1, -3, -13 gene expression. Synovial perfusion data confirm that matriptase activates proteinase activated receptor-2, and matriptase-dependent enhancement of collagenolysis from osteoarthritis cartilage is blocked by proteinase activated receptor-2 inhibition Homo sapiens