Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | auto-activating protease | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | inhibition of matriptase appears to suppress both primar tumor growth and metastasis, leading to considerable interest in the development of potent matriptase inhibitors as anti-cancer drugs | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
amino acid residues 596 to 855 and 615 to 855, corresponding to the active sites and catalytic domains of the peptide, respectively, are expressed with a N-terminal His tag in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha1-antitrypsin | AAT | Homo sapiens | |
hepatocyte growth factor activator inhibitor | HAI-1 | Homo sapiens | |
sunflower trypsin inhibitor | SFTI-1 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
26000 | - |
determined by SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
using a metal chelating column and a gel filtration column | Homo sapiens |
Renatured (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial cell | - |
Homo sapiens | - |
additional information | matriptase is expressed in prostate, breast and colorectal cancers in vitro and in vivo | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
t-butyloxycarbonyl-Gln-Ala-Arg-7-amido-4-methylcoumarin + H2O | enzymatic activity assay | Homo sapiens | t-butyloxycarbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
epithin | - |
Homo sapiens |
matriptase | - |
Homo sapiens |
MT-SP1 | - |
Homo sapiens |
ST14 | - |
Homo sapiens |
suppressor of tumorigenicity 14 | - |
Homo sapiens |
TADG15 | - |
Homo sapiens |
type II transmembrane protease | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9 | - |
enzymatic activity assay | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00000092 | - |
sunflower trypsin inhibitor | - |
Homo sapiens |