Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of matriptase knockout mice | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | matriptase is a type II transmembrane trypsin-like serine protease | Mus musculus | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | a matriptase-prostasin zymogen activation cascade may be functionally operative in multiple epithelial tissues, but matriptase promotes epithelial carcinogenesis independent of prostasin, overview | ? | - |
? | |
pro-prostasin + H2O | Mus musculus | the channel activating protease prostasin/CAP1/PRSS8, a glycosylphosphatidylinositol-anchored membrane serine protease, is co-localized with matriptase | prostasin + propeptide of prostasin | - |
? | |
profilaggrin + H2O | Mus musculus | - |
filaggrin + propeptide of filaggrin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epidermis | - |
Mus musculus | - |
epithelium | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | a matriptase-prostasin zymogen activation cascade may be functionally operative in multiple epithelial tissues, but matriptase promotes epithelial carcinogenesis independent of prostasin, overview | Mus musculus | ? | - |
? | |
pro-prostasin + H2O | the channel activating protease prostasin/CAP1/PRSS8, a glycosylphosphatidylinositol-anchored membrane serine protease, is co-localized with matriptase | Mus musculus | prostasin + propeptide of prostasin | - |
? | |
pro-prostasin + H2O | activation, cleavage after Arg12 within the amino acid sequence QPR12-ITG | Mus musculus | prostasin + propeptide of prostasin | - |
? | |
profilaggrin + H2O | - |
Mus musculus | filaggrin + propeptide of filaggrin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tumor-associated type II transmembrane serine protease | - |
Mus musculus |