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Literature summary for 3.4.21.109 extracted from

  • Jin, X.; Hirosaki, T.; Lin, C.Y.; Dickson, R.B.; Higashi, S.; Kitamura, H.; Miyazaki, K.
    Production of soluble matriptase by human cancer cell lines and cell surface activation of its zymogen by trypsin (2005), J. Cell. Biochem., 95, 632-647.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Epidermal growth factor stimulates the release of matripase/hepatocyte growth factor activator inhibitor-1 complexes Homo sapiens
Trypsin activates membrane-bound, latent matripase on the cell surface Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
Homo sapiens 9986
-
membrane
-
Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
75000
-
by immunoblotting or zymography Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast carcinoma cell
-
Homo sapiens
-
BT-20 cell low level Homo sapiens
-
Colo-201 cell high level Homo sapiens
-
colonic cancer cell line
-
Homo sapiens
-
DLD-1 cell high level Homo sapiens
-
KATO-III cell low level Homo sapiens
-
MCF-7 cell low level Homo sapiens
-
MKN-1 cell low level Homo sapiens
-
MKN-28 cell low level Homo sapiens
-
MKN-45 cell high level Homo sapiens
-
MKN-74 cell high level Homo sapiens
-
additional information stomach carcinoma cell line, low level in AZ521 cell, SCH cell, STKM-2 cell, MDA-MB cell, MMK-29 cell, YLC cell, KKI-cell, LU-65 cell and A549 cell,high level in STKM-1, RCM-1 cell, LU-99 cell and VMRC-LCP cell Homo sapiens
-
NUGC-3 cell low level Homo sapiens
-
SW-480 cell high level Homo sapiens
-
WiDr cell high level Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Boc-Glu-Ala-Arg-7-amido-4-methylcoumarin + H2O
-
Homo sapiens ?
-
?
Gelatin + H2O
-
Homo sapiens ?
-
?