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Literature summary for 3.4.21.109 extracted from
- Inhibition of tumor invasion by genomic down-regulation of matriptase through suppression of activation of receptor-bound pro-urokinase (2004), J. Biol. Chem., 279, 14899-14908.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | matripase mediates cell invasion through activation of receptor-bound pro-urokinase-type plasminogen activator | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| antisense-matripase | significantly reduces matripase protein expression by 70-80%, anti-tumoral activity on HRA cells intraperitoneal injected into nude mice | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 100000 | - |
immunoblotting, matripase-hepatocyte growth factor activator inhibitor-1 complex | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| ovary cancer cell line | HRA cell | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pro-urokinase-type plasminogen activator + H2O | - |
Homo sapiens | ? | - |
? |  |
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