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Literature summary for 3.4.21.108 extracted from

  • Rodrigue-Gervais, I.G.; Doiron, K.; Champagne, C.; Mayes, L.; Leiva-Torres, G.A.; Vanie, P.; Douglas, T.; Vidal, S.M.; Alnemri, E.S.; Saleh, M.
    The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes (2018), Sci. Rep., 8, 8446 .
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Mus musculus Q9JIY5
-
-

General Information

General Information Comment Organism
physiological function protease HtrA2 restricts the activation of apoptosis-associated speck-like protein containing a caspase-recruitment domain, i.e. ASC, dependent NLRP3 and AIM2 inflammasomes, in a protease activity-dependent manner. Disruption of the protease activity of HtrA2 results in exacerbated NLRP3 and AIM2 inflammasome responses in macrophages ex vivo and systemically in vivo. HtrA2 protease activity regulates autophagy and controls the magnitude and duration of inflammasome signaling by preventing prolonged accumulation of the inflammasome adaptor ASC Mus musculus