Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9JIY5 | - |
- |
General Information | Comment | Organism |
---|---|---|
physiological function | protease HtrA2 restricts the activation of apoptosis-associated speck-like protein containing a caspase-recruitment domain, i.e. ASC, dependent NLRP3 and AIM2 inflammasomes, in a protease activity-dependent manner. Disruption of the protease activity of HtrA2 results in exacerbated NLRP3 and AIM2 inflammasome responses in macrophages ex vivo and systemically in vivo. HtrA2 protease activity regulates autophagy and controls the magnitude and duration of inflammasome signaling by preventing prolonged accumulation of the inflammasome adaptor ASC | Mus musculus |