Application | Comment | Organism |
---|---|---|
medicine | therapeutic interventions that inhibit HtrA2/Omi expression, translocation, or protease activity may represent novel therapeutic strategies for retinal pigment epithelial cells and retinal pigment epithelial cells-related diseases | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ucf-101 | treatment of retinal epithelial cells with UCF-101 reduces the cytosolic translocation of HtrA2/Omi, attenuates caspase-3 activation, and decreases apoptosis | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | H2O2-induced oxidative damage of retinal pigment epithelial cells results in HtrA2/Omi translocation from mitochondria to cytosol, leading to RPE cell apoptosis via a caspase-mediated pathway | Mus musculus | 5829 | - |
mitochondrion | - |
Mus musculus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Synonyms | Comment | Organism |
---|---|---|
HtrA2/Omi | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | after specific HtrA2 downregulation using RNAi, increased cell viability is measured in H2O2-treated ARPE-19 cells | down |
General Information | Comment | Organism |
---|---|---|
malfunction | fewer and abnormal mitochondria are found in HtrA2/Omi knockout mice photoreceptors and pigment epithelial cells | Mus musculus |