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Literature summary for 3.4.21.108 extracted from

  • Liu, H.R.; Gao, E.; Hu, A.; Tao, L.; Qu, Y.; Most, P.; Koch, W.J.; Christopher, T.A.; Lopez, B.L.; Alnemri, E.S.; Zervos, A.S.; Ma, X.L.
    Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion (2005), Circulation, 111, 90-96.
    View publication on PubMed
Search for more literature for 3.4.21.108

Application

Application Comment Organism
medicine myocardial ischemia/reperfusion significantly increases cytosolic Omi/HtrA2 content and markedly increases apoptosis, ucf-101 can inhibit apoptosis Mus musculus
medicine transfecting cells with siRNA molecules against Omi effectively eliminate Omi/HtrA2 protein expression Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information ucf-101 fails to exert any additional protective effect in transfected cells Rattus norvegicus
ucf-101 blocks HtrA2 protease activity, inhibition of apoptosis Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol myocardial ischemia/reperfusion results in Omi/HtrA2 translocation from the mitochondria to the cytosol along with cytochrome c Mus musculus 5829
-
mitochondrion
-
 Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Mus musculus
-
heart neonatal ventricular cardiomyocytes Rattus norvegicus
-
myocardium
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
X-linked inhibitor of apoptosis protein HtrA2 promotes degradation of the X-linked inhibitor of apoptosis protein followed by subsequent caspase activation Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
Omi/HtrA2
-
 Mus musculus
Omi/HtrA2
-
 Rattus norvegicus