Literature summary for 3.4.21.107 extracted from

Lentini, G.; El Hajj, H.; Papoin, J.; Fall, G.; Pfaff, A.W.; Tawil, N.; Braun-Breton, C.; Lebrun, M.
Characterization of Toxoplasma DegP, a rhoptry serine protease crucial for lethal infection in mice (2017), PLoS ONE, 12, e0189556 .

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Organism

Organism	UniProt	Comment	Textmining
Toxoplasma gondii	-	-	-

Subunits

Subunits	Comment	Organism
?	x * 104000, calculated from sequence for full-length protein, x * 60000, mature C-terminal fragment, * 40000, mature N-terminal fragment, SDS-PAGE	Toxoplasma gondii

Synonyms

Synonyms	Comment	Organism
DegP	-	Toxoplasma gondii

General Information

General Information	Comment	Organism
physiological function	disruption of the DegP gene does not impact the parasite lytic cycle in vitro but affects virulence in mice. In a type I strain, DegP appears dispensable for the establishment of an infection, but removal of DegP in a type II strain dramatically impairs the virulence. Type II parasites lacking DegP activity kill immunodeficient mice as efficiently as the wild-type strain	Toxoplasma gondii

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Release 2023.1 (January 2023)