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Literature summary for 3.4.21.107 extracted from

  • Poepsel, S.; Sprengel, A.; Sacca, B.; Kaschani, F.; Kaiser, M.; Gatsogiannis, C.; Raunser, S.; Clausen, T.; Ehrmann, M.
    Determinants of amyloid fibril degradation by the PDZ protease HTRA1 (2015), Nat. Chem. Biol., 11, 862-869 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92743
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protein tau + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
HtrA1
-
Homo sapiens

General Information

General Information Comment Organism
physiological function HTRA1 degrades amyloid fibrils in an ATP-independent manner. HTRA1 solubilizes protein fibrils and disintegrates the fibrillar core structure. The proteolytic mechanism of HTRA1 toward fibrils is initiated along the entire length of amyloid fibrils, comprises disintegration of tightly packed regions, which is enhanced by the binding of specific sequences by the C-terminal PDZ domain, and ultimately results in the efficient proteolytic removal of amyloid fibrils. Deletion of the PDZ domain severely impairs the destabilization of tau fibrils in vitro and in cultured cells Homo sapiens