Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q92743 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
protein tau + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HtrA1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | HTRA1 degrades amyloid fibrils in an ATP-independent manner. HTRA1 solubilizes protein fibrils and disintegrates the fibrillar core structure. The proteolytic mechanism of HTRA1 toward fibrils is initiated along the entire length of amyloid fibrils, comprises disintegration of tightly packed regions, which is enhanced by the binding of specific sequences by the C-terminal PDZ domain, and ultimately results in the efficient proteolytic removal of amyloid fibrils. Deletion of the PDZ domain severely impairs the destabilization of tau fibrils in vitro and in cultured cells | Homo sapiens |