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Literature summary for 3.4.21.107 extracted from

  • Kummari, R.; Dutta, S.; Chaganti, L.K.; Bose, K.
    Discerning the mechanism of action of HtrA4 a serine protease implicated in the cell death pathway (2019), Biochem. J., 476, 1445-1463 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Protein Variants

Protein Variants Comment Organism
S326A mutation in active site, inactive Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
120000
-
gel fitration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P83105 isoform HtrA4
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-casein + H2O
-
Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
trimer 3 * 36000, calculated from sequence Homo sapiens

Synonyms

Synonyms Comment Organism
HTRA4
-
Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
58
-
melting temperature, wild-type and mutant S326A Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
12.3
-
beta-casein pH 8.0, 37°C Homo sapiens