Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diisopropyl fluorophosphate | - |
Plasmodium falciparum | |
additional information | not inhibitory: dithiothreitol, phenylmethanesulfonyl fluoride, leupeptin, E-64 and pepstatin | Plasmodium falciparum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0346 | - |
succinyl-Leu-Leu-Val-Tyr-4-methylcoumarin 7-amide | pH 7.0, temperature not specified in the publication | Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | Q8IAR5 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | maximum transcription is observed in trophozoite- and schizont-stage parasites, with no detectable transcription observed at the ring stage | Plasmodium falciparum | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinyl-Leu-Leu-Val-Tyr-4-methylcoumarin 7-amide + H2O | - |
Plasmodium falciparum | succinyl-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DegP | - |
Plasmodium falciparum |
MAL8P1.126 | - |
Plasmodium falciparum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
- |
Plasmodium falciparum |
Organism | Comment | Expression |
---|---|---|
Plasmodium falciparum | expression is significantly induced in parasite culture upon heat shock/oxidative stress | up |
General Information | Comment | Organism |
---|---|---|
physiological function | Plasmodium falciparum PfDegP complements the growth defect of the temperature sensitive DegP-deficient mutant in Escherichia coli and imparts resistance to non-permissive temperatures and oxidative stress. DegP exists as a complex with parasite-encoded heat shock protein 70, iron superoxide dismutase and enolase | Plasmodium falciparum |