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Literature summary for 3.4.21.107 extracted from

  • Sharma, S.; Jadli, M.; Singh, A.; Arora, K.; Malhotra, P.
    A secretory multifunctional serine protease, DegP of Plasmodium falciparum, plays an important role in thermo-oxidative stress, parasite growth and development (2014), FEBS J., 281, 1679-1699.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
diisopropyl fluorophosphate
-
Plasmodium falciparum
additional information not inhibitory: dithiothreitol, phenylmethanesulfonyl fluoride, leupeptin, E-64 and pepstatin Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0346
-
succinyl-Leu-Leu-Val-Tyr-4-methylcoumarin 7-amide pH 7.0, temperature not specified in the publication Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum Q8IAR5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information maximum transcription is observed in trophozoite- and schizont-stage parasites, with no detectable transcription observed at the ring stage Plasmodium falciparum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinyl-Leu-Leu-Val-Tyr-4-methylcoumarin 7-amide + H2O
-
Plasmodium falciparum succinyl-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin
-
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Synonyms

Synonyms Comment Organism
DegP
-
Plasmodium falciparum
MAL8P1.126
-
Plasmodium falciparum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Plasmodium falciparum

Expression

Organism Comment Expression
Plasmodium falciparum expression is significantly induced in parasite culture upon heat shock/oxidative stress up

General Information

General Information Comment Organism
physiological function Plasmodium falciparum PfDegP complements the growth defect of the temperature sensitive DegP-deficient mutant in Escherichia coli and imparts resistance to non-permissive temperatures and oxidative stress. DegP exists as a complex with parasite-encoded heat shock protein 70, iron superoxide dismutase and enolase Plasmodium falciparum