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Literature summary for 3.4.21.107 extracted from

  • Zhang, L.; Lim, S.L.; Du, H.; Zhang, M.; Kozak, I.; Hannum, G.; Wang, X.; Ouyang, H.; Hughes, G.; Zhao, L.; Zhu, X.; Lee, C.; Su, Z.; Zhou, X.; Shaw, R.; Geum, D.; Wei, X.; Zhu, J.; Ideker, T.; Oka, C.; Wang, N.; Yang, Z.; Shaw, P.X.; Zhang, K.
    HTRA1 regulates angiogenesis through TGF-beta family member GDF6 (2012), J. Biol. Chem., 287, 1520-1526.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.107

Organism

Organism UniProt Comment Textmining
Mus musculus
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Synonyms

Synonyms Comment Organism
high-temperature requirement A protease
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 Mus musculus
HtrA
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 Mus musculus

Expression

Organism Comment Expression
Mus musculus the growth differentiation factor 6 age-related macular degeneration risk allele (rs6982567 A) is associated with 70% increased expression of HTRA1. The HTRA1 age-related macular degeneration risk allele (rs10490924 T) is associated with 94% increased HTRA1 expression up

General Information

General Information Comment Organism
malfunction HTRA1 knockout mice display reduced blood vessel in retina and upregulation of growth differentiation factor 6 Mus musculus
physiological function HTRA1 plays a critical role in the regulation of angiogenesis via transforming growth factor-beta signaling Mus musculus